Repression of prostaglandin dehydrogenase by epidermal growth factor and snail increases prostaglandin E2 and promotes cancer progression.

@article{Mann2006RepressionOP,
  title={Repression of prostaglandin dehydrogenase by epidermal growth factor and snail increases prostaglandin E2 and promotes cancer progression.},
  author={Jason R Mann and Michael G Backlund and F. Gregory Buchanan and Taki Daikoku and Vijaykumar R. Holla and Daniel W Rosenberg and Sudhansu K Dey and Raymond N. Dubois},
  journal={Cancer research},
  year={2006},
  volume={66 13},
  pages={6649-56}
}
Prostaglandin E(2) (PGE(2)), a proinflammatory bioactive lipid, promotes cancer progression by modulating proliferation, apoptosis, and angiogenesis. PGE(2) is a downstream product of cyclooxygenase (COX) and is biochemically inactivated by prostaglandin dehydrogenase (PGDH). In the present study, we investigated the mechanisms by which PGDH is down-regulated in cancer. We show that epidermal growth factor (EGF) represses PGDH expression in colorectal cancer cells. EGF receptor (EGFR) signaling… CONTINUE READING