Repression of promoter activity by CNOT2, a subunit of the transcription regulatory Ccr4-not complex.

Abstract

The evolutionary conserved Ccr4-Not complex controls mRNA metabolism at multiple levels in eukaryotic cells. Genetic analysis of not mutants in yeast identifies a negative role in transcription, which is dependent on core promoter structure. To obtain direct support for this we targeted individual core subunits of the human Ccr4-Not complex to promoters in… (More)

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@article{Zwartjes2004RepressionOP, title={Repression of promoter activity by CNOT2, a subunit of the transcription regulatory Ccr4-not complex.}, author={Carin G M Zwartjes and Sandrine Jayne and Debbie L. C. van den Berg and H. Th. Marc Timmers}, journal={The Journal of biological chemistry}, year={2004}, volume={279 12}, pages={10848-54} }