Repression of preprotachykinin-A promoter activity is mediated by a proximal promoter element.

@article{Mendelson1995RepressionOP,
  title={Repression of preprotachykinin-A promoter activity is mediated by a proximal promoter element.},
  author={Steven Mendelson and Christine F. Morrison and Jane McAllister and Janice M Paterson and S P Dobson and P. K. Mulderry and J P Quinn},
  journal={Neuroscience},
  year={1995},
  volume={65 3},
  pages={837-47}
}
The rat preprotachykinin-A promoter, which is able to direct reporter gene expression in adult dorsal root ganglia neurons grown in culture, has no detectable activity in HeLa and PC12 cells. DNAase 1 footprinting and electrophoretic mobility shift analyses with HeLa nuclear extract indicated the presence of a protein complex binding to a region of the rat preprotachykinn-A gene promoter between the TATA box and the major transcriptional start site. We demonstrate that the sequence of the… CONTINUE READING