Repression of p15INK4b expression by Myc through association with Miz-1

@article{Staller2001RepressionOP,
  title={Repression of p15INK4b expression by Myc through association with Miz-1},
  author={P. Staller and K. Peukert and A. Kiermaier and J. Seoane and J. Lukas and H. Karsunky and T. M{\"o}r{\"o}y and J. Bartek and J. Massagu{\'e} and F. H{\"a}nel and M. Eilers},
  journal={Nature Cell Biology},
  year={2001},
  volume={3},
  pages={392-399}
}
Deregulated expression of c-myc can induce cell proliferation in established cell lines and in primary mouse embryonic fibroblasts (MEFs), through a combination of both transcriptional activation and repression by Myc. [...] Key Result Miz-1 upregulates expression of the cyclin-dependent kinases (CDK) inhibitor p15INK4b by binding to the initiator element of the p15INK4b promoter. Myc and Max form a complex with Miz-1 at the p15 initiator and inhibit transcriptional activation by Miz-1.Expand
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