Repression of organizer genes in dorsal and ventral Xenopus cells mediated by maternal XTcf3.

@article{Houston2002RepressionOO,
  title={Repression of organizer genes in dorsal and ventral Xenopus cells mediated by maternal XTcf3.},
  author={Douglas W Houston and Matt Kofron and Ernesto R Resnik and Rachel A Langland and Olivier H. J. Destr{\'e}e and Christopher Wylie and Janet Heasman},
  journal={Development},
  year={2002},
  volume={129 17},
  pages={4015-25}
}
In the early Xenopus embryo, the dorsal axis is specified by a Wnt signal transduction pathway, involving the movement of beta-catenin into dorsal cell nuclei and its functional association with the LEF-type transcription factor XTcf3. The subsequent function of XTcf3 is uncertain. Overexpression data has suggested that it can be both an activator and repressor of downstream genes. XTcf3 mRNA is synthesized during oogenesis in Xenopus and is stored in the egg. To identify its role in dorsal… CONTINUE READING
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