Repression of insulin gene transcription by indirect genomic signaling via the estrogen receptor in pancreatic beta cells

@inproceedings{Sekido2019RepressionOI,
  title={Repression of insulin gene transcription by indirect genomic signaling via the estrogen receptor in pancreatic beta cells},
  author={Takashi Sekido and Shin-Ichi Nishio and Yohsuke Ohkubo and Keiko Sekido and Junichiro Kitahara and Takahide Miyamoto and Mitsuhisa Komatsu},
  booktitle={In Vitro Cellular & Developmental Biology - Animal},
  year={2019}
}
The mechanism whereby 17β-estradiol (E2) mediates insulin gene transcription has not been fully elucidated. In this study, exposure of hamster insulinoma (HIT-T15) cells to 5 × 10−9 to 1 × 10−7 M E2 led to a concentration-dependent decrease of insulin mRNA levels. Transient expression of the estrogen receptor (ER) in HIT-T15 cells revealed that estrogen receptor α (ERα) repressed transcription of the rat insulin II promoter in both ligand-dependent and ligand-independent manners. The N-terminal… CONTINUE READING
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