Repression of hepatobiliary transporters and differential regulation of classic and alternative bile acid pathways in mice during pregnancy.

@article{Aleksunes2012RepressionOH,
  title={Repression of hepatobiliary transporters and differential regulation of classic and alternative bile acid pathways in mice during pregnancy.},
  author={Lauren M Aleksunes and Ronnie L Yeager and Xia Wen and Julia Yue Cui and Curtis D. Klaassen},
  journal={Toxicological sciences : an official journal of the Society of Toxicology},
  year={2012},
  volume={130 2},
  pages={
          257-68
        }
}
During pregnancy, proper hepatobiliary transport and bile acid synthesis protect the liver from cholestatic injury and regulate the maternal and fetal exposure to bile acids, drugs, and environmental chemicals. The objective of this study was to determine the temporal messenger RNA (mRNA) and protein profiles of uptake and efflux transporters as well as bile acid synthetic and conjugating enzymes in livers from virgin and pregnant mice on gestational days (GD) 7, 11, 14, and 17 and postnatal… CONTINUE READING

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