Repression of classical nuclear export by S-nitrosylation of CRM1.

  title={Repression of classical nuclear export by S-nitrosylation of CRM1.},
  author={Peng Jie Wang and Guang-Hui Liu and Kaiyuan Wu and Jing Qu and Bo Huang and Xu Zhang and Xixi Zhou and Larry Gerace and Chang Chen},
  journal={Journal of cell science},
  volume={122 Pt 20},
The karyopherin chromosomal region maintenance 1 (CRM1) is the major receptor for classical nuclear protein export. However, little is known about the regulation of CRM1 itself. Here, we report that cellular CRM1 became S-nitrosylated after extensive exposure to endogenous or exogenous nitric oxide (NO). This abrogated the interaction of CRM1 with nuclear export signals (NESs) and repressed classical protein export. Analysis by mass spectrometry and involving the use of S-nitrosylation mimetic… CONTINUE READING


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