Repression of beta-catenin function in malignant cells by nonsteroidal antiinflammatory drugs.

@article{Lu2005RepressionOB,
  title={Repression of beta-catenin function in malignant cells by nonsteroidal antiinflammatory drugs.},
  author={Desheng Lu and Howard B Cottam and Maripat Corr and Dennis Anthony Carson},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={2005},
  volume={102 51},
  pages={18567-71}
}
Activation of the Wnt/beta-catenin pathway promotes the development of several cancers and is an attractive target for chemopreventive and chemotherapeutic agents. Nonsteroidal antiinflammatory drugs (NSAIDs) have been reported to antagonize beta-catenin function, but their mechanism of action is not known. We demonstrate here that interference with beta-catenin function by NSAIDs does not correlate with cyclooxygenase (COX) inhibition. Instead, NSAID inhibition of beta-catenin requires the… CONTINUE READING

Citations

Publications citing this paper.
Showing 1-10 of 22 extracted citations

Intestinal Tumorigenesis

Springer International Publishing • 2015

Wnt1 positively regulates CD36 expression via TCF4 and PPAR-γ in macrophages.

Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology • 2015

Similar Papers

Loading similar papers…