Repression of alpha-actinin SM exon splicing by assisted binding of PTB to the polypyrimidine tract.

@article{Matlin2007RepressionOA,
  title={Repression of alpha-actinin SM exon splicing by assisted binding of PTB to the polypyrimidine tract.},
  author={Arianne J. Matlin and Justine Southby and Clare Gooding and Christopher W. J. Smith},
  journal={RNA},
  year={2007},
  volume={13 8},
  pages={1214-23}
}
Polypyrimidine tract binding protein (PTB) acts as a regulatory repressor of a large number of alternatively spliced exons, often requiring multiple binding sites in order to repress splicing. In one case, cooperative binding of PTB has been shown to accompany repression. The SM exon of the alpha-actinin pre-mRNA is also repressed by PTB, leading to inclusion of the alternative upstream NM exon. The SM exon has a distant branch point located 386 nt upstream of the exon with an adjacent 26… CONTINUE READING