Repression of activator protein-1-mediated transcriptional activation by the Notch-1 intracellular domain.

Abstract

Developmental decisions that control cell fate are commonly regulated by the Notch signaling pathway. Activation of transmembrane Notch receptors results in proteolytic liberation of the intracellular domain of Notch, which translocates into the nucleus, binds a repressor (C promoter binding factor 1/RBP-Jkappa, Su(H), and Lag-1 (CSL)), and induces target… (More)

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Cite this paper

@article{Chu2002RepressionOA, title={Repression of activator protein-1-mediated transcriptional activation by the Notch-1 intracellular domain.}, author={Jianlin Chu and Shawn K Jeffries and Jason E Norton and Anthony J. Capobianco and Emery H. Bresnick}, journal={The Journal of biological chemistry}, year={2002}, volume={277 9}, pages={7587-97} }