Repression of a herpes simplex virus immediate-early promoter by the Oct-2 transcription factor is dependent on an inhibitory region at the N terminus of the protein.

@article{Lillycrop1994RepressionOA,
  title={Repression of a herpes simplex virus immediate-early promoter by the Oct-2 transcription factor is dependent on an inhibitory region at the N terminus of the protein.},
  author={K. A. Lillycrop and Sally J Dawson and J K Estridge and Thomas Gerster and Patrick D. Matthias and D. S. Latchman},
  journal={Molecular and cellular biology},
  year={1994},
  volume={14 11},
  pages={7633-42}
}
The B-cell form of the Oct-2 transcription factor Oct 2.1 can activate the herpes simplex virus immediate-early gene 3 (IE3) promoter, whereas the neuronally expressed Oct 2.4 and 2.5 forms of the protein, which contain a different C terminus, can repress this promoter. Here we show that partial or full deletion of the C terminus of Oct 2.1 in the presence of an intact N terminus results in a protein which can strongly repress the IE3 promoter. In contrast, deletion of the entire N terminus or… CONTINUE READING