Repression of TGF-β signaling by the oncogenic protein SKI in human melanomas: consequences for proliferation, survival, and metastasis

@article{Medrano2003RepressionOT,
  title={Repression of TGF-β signaling by the oncogenic protein SKI in human melanomas: consequences for proliferation, survival, and metastasis},
  author={Estela E. Medrano},
  journal={Oncogene},
  year={2003},
  volume={22},
  pages={3123-3129}
}
Transforming growth factor-β (TGF-β) has dual and paradoxical functions as a tumor suppressor and promoter of tumor progression and metastasis. TGF-β-mediated growth inhibition is gradually lost during melanoma tumor progression, but there are no measurable defects at the receptor level. Furthermore, melanoma cells release high levels of TGF-β to the microenvironment, which upon activation induces matrix deposition, angiogenesis, survival, and transition to more aggressive phenotypes. The SKI… CONTINUE READING

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Hum

  • SB Baylin, M Esteller, MR Rountree, KE Bachman, K Schuebel, JG. Herman
  • Mol. Genet., 10, 687–692.
  • 2001
1 Excerpt

Nat

  • CW Jang, CH Chen, CC Chen, JJ Chen, YH Su, RH. Chen
  • Cell Biol.
  • 2001

Semin

  • FC Yang, G Merlino, L. Chin
  • Cancer Biol., 11, 261–268.
  • 2001
2 Excerpts

Mech

  • CD Kaufman, G Martinez-Rodriguez, PB. Hackett
  • Dev., 95, 147–162.
  • 2000
2 Excerpts

Proc

  • W Xu, K Angelis, +5 authors EE. Medrano
  • Natl. Acad. Sci. USA, 97, 5924–5929.
  • 2000

Int

  • B Janji, C Melchior, V Gouon, L Vallar, N. Kieffer
  • J. Cancer, 83, 255–262.
  • 1999
1 Excerpt

Mol

  • L Zawel, JL Dai, +4 authors SE. Kern
  • Cell, 1, 611–617.
  • 1998

Biochem

  • K Ichikawa, T Nagase, S Ishii, A Asano, N. Mimura
  • J., 328, 607–613.
  • 1997

J

  • G Zheng, KM Blumenthal, Y Ji, DL Shardy, SB Cohen, E. Stavnezer
  • Biol. Chem., 272, 31855–31864.
  • 1997

Dev

  • D Shardy, E. Stavnezer
  • Dyn., 201, 354–365. Massague J and Chen YG. (2000…
  • 1994

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