Repression of Six3 by a corepressor regulates rhodopsin expression.

  title={Repression of Six3 by a corepressor regulates rhodopsin expression.},
  author={Bramanandam Manavathi and Shaohua Peng and Suresh K Rayala and A. B. M. Hasan Talukder and Minhua H Wang and Rui-an Wang and Seetharaman Balasenthil and Neeraj Agarwal and Laura Frishman and Rakesh Kumar},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  volume={104 32},
Here, we provide gain-of-function, loss-of function, and molecular evidence supporting genetic interactions between metastasis associated protein 1 (MTA1) and Six3 and between Six3 and rhodopsin. We discovered that MTA1 physically interacts with the Six3 chromatin in a histone deacetylase-dependent manner, leading to transcriptional suppression of the Six3 gene. MTA1 is also a Six3-interacting corepressor that contributes to a self-negative regulation of Six3 transcription by Six3. In contrast… CONTINUE READING


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