Repression of STAT3, STAT5A, and STAT5B expressions in chronic myelogenous leukemia cell line K–562 with unmodified or chemically modified siRNAs and induction of apoptosis

@article{Kaymaz2012RepressionOS,
  title={Repression of STAT3, STAT5A, and STAT5B expressions in chronic myelogenous leukemia cell line K–562 with unmodified or chemically modified siRNAs and induction of apoptosis},
  author={Burçin Tezcanlı Kaymaz and N. Senthamarai Selvi and Cumhur G{\"u}nd{\"u}z and Çağdaş Aktan and Ayşeg{\"u}l Dalmızrak and G{\"u}ray Saydam and Buket Kosova},
  journal={Annals of Hematology},
  year={2012},
  volume={92},
  pages={151-162}
}
Signal transducers and activators of transcription (STAT) proteins are latent cytoplasmic transcription factors that affect several cellular processes including cell growth, proliferation, differentiation, and survival. Following phosphorylation, STATs are activated, and their upregulated expressions increase in malignancies with playing a role in the development of leukemia. In this study, transfection of K–562 cells with either unmodified or chemically modified anti-STAT3, -STAT5A, -STAT5B… CONTINUE READING