Repression of RNA polymerase III transcription by the retinoblastoma protein

  title={Repression of RNA polymerase III transcription by the retinoblastoma protein},
  author={Robert J. White and Didier Trouche and Klaus Martin and Stephen P. Jackson and Tony Kouzarides},
TRANSCRIPTION by RNA polymerase (pol) III is under cell-cycle control, being higher in S and G2 than in G0 and early G1 phases1–4. Many transformed cell types have elevated pol III activity4–9, presumably to sustain sufficient protein synthesis for unrestrained growth. The retinoblastoma tumour-suppressor protein (Rb) restricts cellular proliferation, and is often found mutated in transformed cells10,11. Here we demonstrate that Rb can repress the level of transcription from pol III templates… CONTINUE READING

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