Repression of Pumilio Protein Expression by Rbfox1 Promotes Germ Cell Differentiation.

@article{CarreiraRosario2016RepressionOP,
  title={Repression of Pumilio Protein Expression by Rbfox1 Promotes Germ Cell Differentiation.},
  author={Arnaldo Carreira-Rosario and Varsha Bhargava and Jens Hillebrand and Rahul K. Kollipara and Mani Ramaswami and Michael Buszczak},
  journal={Developmental cell},
  year={2016},
  volume={36 5},
  pages={562-71}
}
RNA-binding Fox (Rbfox) proteins have well-established roles in regulating alternative splicing, but specific Rbfox isoforms lack nuclear localization signals and accumulate in the cytoplasm. The potential splicing-independent functions of these proteins remain unknown. Here we demonstrate that cytoplasmic Drosophila Rbfox1 regulates germ cell development… CONTINUE READING