Repression of MUC2 gene expression by butyrate, a physiological regulator of intestinal cell maturation

  title={Repression of MUC2 gene expression by butyrate, a physiological regulator of intestinal cell maturation},
  author={Leonard H. Augenlicht and Li Shi and John M. Mariadason and Christian L. Laboisse and Anna Velcich},
Sodium butyrate (NaB) inhibits proliferation, stimulates apoptosis, and promotes differentiation of human colon cancer cells along the absorptive phenotype. In vitro, butyrate induces a switch from cells with a secretory to an absorptive phenotype. Here, we report that NaB specifically represses the expression of the MUC2 gene, a differentiation marker of the secretory goblet cell lineage, in forskolin- and 12-O-tetradecanoylphorbol 13-acetate-induced HT29 cells, and Cl.16E cells, a clonal… CONTINUE READING


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