Repression of Intestinal Stem Cell Function and Tumorigenesis through Direct Phosphorylation of β-Catenin and Yap by PKCζ

@article{Llado2015RepressionOI,
  title={Repression of Intestinal Stem Cell Function and Tumorigenesis through Direct Phosphorylation of β-Catenin and Yap by PKCζ},
  author={Victoria Llado and Yuki Nakanishi and Angeles Dur{\'a}n and Miguel Reina-Campos and Phillip M. Shelton and Juan F. Linares and Tomoko Yajima and Alex D Campos and Pedro Aza-Blanc and Michael Leitges and Mar{\'i}a Teresa D{\'i}az-Meco and Jorge Moscat},
  journal={Cell reports},
  year={2015}
}
Intestinal epithelial homeostasis requires continuous renewal supported by stem cells located in the base of the crypt. Disruption of this balance results in failure to regenerate and initiates tumorigenesis. The β-catenin and Yap pathways in Lgr5+ stem cells have been shown to be central to this process. However, the precise mechanisms by which these signaling molecules are regulated in the stem cell population are not totally understood. Protein kinase C ζ (PKCζ) has been previously… CONTINUE READING
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