Repression of IFN regulatory factor 8 by DNA methylation is a molecular determinant of apoptotic resistance and metastatic phenotype in metastatic tumor cells.

@article{Yang2007RepressionOI,
  title={Repression of IFN regulatory factor 8 by DNA methylation is a molecular determinant of apoptotic resistance and metastatic phenotype in metastatic tumor cells.},
  author={Dafeng Yang and Muthusamy Thangaraju and Kristy M. Greeneltch and Darren D Browning and Patricia Veronica Schoenlein and Tomohiko Tamura and Keiko Ozato and Vadivel Ganapathy and Scott I Abrams and Kebin Liu},
  journal={Cancer research},
  year={2007},
  volume={67 7},
  pages={3301-9}
}
Apoptotic resistance is often associated with metastatic phenotype in tumor cells and is considered a hallmark of tumor progression. In this study, IFN regulatory factor 8 (IRF8) expression was found to be inversely correlated with an apoptotic-resistant and metastatic phenotype in human colon carcinoma cell lines in vitro. This inverse correlation was… CONTINUE READING