Repression of Ets-2-induced transactivation of the tau interferon promoter by Oct-4.

@article{Ezashi2001RepressionOE,
  title={Repression of Ets-2-induced transactivation of the tau interferon promoter by Oct-4.},
  author={Toshihiko Ezashi and Dolly Ghosh and R Michael Roberts},
  journal={Molecular and cellular biology},
  year={2001},
  volume={21 23},
  pages={7883-91}
}
Oct-4 is a POU family transcription factor associated with potentially totipotent cells. Genes expressed in the trophectoderm but not in embryos prior to blastocyst formation may be targets for silencing by Oct-4. Here, we have tested this hypothesis with the tau interferon genes (IFNT genes), which are expressed exclusively in the trophectoderm of bovine embryos. IFNT promoters contain an Ets-2 enhancer, located at -79 to -70, and are up-regulated about 20-fold by the overexpression of Ets-2… CONTINUE READING

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