Repression of BCL2 by the tumor suppressor activity of the lysyl oxidase propeptide inhibits transformed phenotype of lung and pancreatic cancer cells.

@article{Wu2007RepressionOB,
  title={Repression of BCL2 by the tumor suppressor activity of the lysyl oxidase propeptide inhibits transformed phenotype of lung and pancreatic cancer cells.},
  author={Min Wu and Chengyin Min and Xiaobo Wang and Ziyang Yu and Kathrin Kirsch and Philip C Trackman and Gail E. Sonenshein},
  journal={Cancer research},
  year={2007},
  volume={67 13},
  pages={6278-85}
}
The gene encoding lysyl oxidase (LOX) was identified as the ras recision gene (rrg), with the ability to revert Ras-mediated transformation of NIH 3T3 fibroblasts. Mutations in RAS genes have been found in approximately 25% of lung cancers and in 85% of pancreatic cancers. In microarray analysis, these cancers were found to display reduced LOX gene expression. Thus, the ability of the LOX gene to repress the transformed phenotype of these cancer cells was tested. LOX is synthesized as a 50-kDa… CONTINUE READING