Repression of BCL-6 is required for the formation of human memory B cells in vitro

@article{Kuo2007RepressionOB,
  title={Repression of BCL-6 is required for the formation of human memory B cells in vitro},
  author={Tracy C. Kuo and Arthur L Shaffer and Joseph Haddad and Yong Sung Choi and Louis M. Staudt and Kathryn L. Calame},
  journal={The Journal of Experimental Medicine},
  year={2007},
  volume={204},
  pages={819 - 830}
}
Memory B cells provide rapid protection to previously encountered antigens; however, how these cells develop from germinal center B cells is not well understood. A previously described in vitro culture system using human tonsillar germinal center B cells was used to study the transcriptional changes that occur during differentiation of human memory B cells. Kinetic studies monitoring the expression levels of several known late B cell transcription factors revealed that BCL-6 is not expressed in… CONTINUE READING