Repression by binding of H-NS within the transcription unit.

  title={Repression by binding of H-NS within the transcription unit.},
  author={V Nagarajavel and Srinivasan Madhusudan and Sudhanshu Dole and Abdelkader Rahmouni and Karin Schnetz},
  journal={The Journal of biological chemistry},
  volume={282 32},
H-NS inhibits transcription by forming repressing nucleoprotein complexes next to promoters. We investigated repression by binding of H-NS within the transcription unit using the bgl and proU operons. Repression of both operons requires a downstream regulatory element (DRE) in addition to an upstream element (URE). In bgl, H-NS binds to a region located between 600 to 700 bp downstream of the transcription start site, whereas in proU the DRE extends up to position +270. We show that binding of… CONTINUE READING

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