Representation of capsaicin-evoked urge-to-cough in the human brain using functional magnetic resonance imaging.

@article{Mazzone2007RepresentationOC,
  title={Representation of capsaicin-evoked urge-to-cough in the human brain using functional magnetic resonance imaging.},
  author={Stuart B. Mazzone and Lisa McLennan and Alice E. McGovern and Gary F. Egan and Michael J. Farrell},
  journal={American journal of respiratory and critical care medicine},
  year={2007},
  volume={176 4},
  pages={327-32}
}
RATIONALE Coughing in humans is typically preceded by a desire (or urge) to cough. The neural circuitry involved in sensing airway irritation and generating the urge-to-cough in humans is essentially unknown. OBJECTIVES The aim of the present study was to use functional brain imaging to describe the supramedullary regions that are activated in humans during capsaicin inhalation. METHODS Experiments were performed on 10 healthy subjects (5 males, 5 females). Capsaicin doses were individually… CONTINUE READING