Reports of 355 transfusion‐associated deaths: 1976 through 1985

  title={Reports of 355 transfusion‐associated deaths: 1976 through 1985},
  author={Kathleen Sazama},
  • K. Sazama
  • Published 1 September 1990
  • Medicine
  • Transfusion
From 1976 through 1985, the United States Food and Drug Administration received reports of 355 fatalities associated with transfusion, 99 of which were excluded from further review because they were unrelated to transfusion or involved hepatitis or acquired immune deficiency syndrome. Of the remaining 256 reported deaths, 51 percent resulted from acute hemolysis following the transfusion of ABO‐incompatible products. These deaths were due primarily to managerial, not clerical, errors. Other… 

Serious hazards of transfusion (SHOT) initiative: analysis of the first two annual reports

Transfusion is now extremely safe, but vigilance is needed to ensure correct identification of blood and patient, and staff education should include awareness of ABO incompatibility and bacterial contamination as causes of life threatening reactions to blood.

A report of 104 transfusion errors in New York State

The risk of transfusion of ABO‐incompatible blood remains significant, and additional precautions to minimize the likelihood of such events should be considered.

Transfusion: Morbidity and Mortality

Transfusion-related mortality and morbidity data is infrequently reported, and a significant number of such deaths are attributable to misidentification of patient or units and are preventable by obsessional attention to clerical details.

Transfusion-related acute lung injury: report of a clinical look-back investigation.

TRALI was frequently underdiagnosed and underreported in recipients of blood products from a donor whose blood products may have caused TRALI in several transfusion recipients.

Transfusion‐associated adverse pulmonary sequelae: widening our perspective

Interest in a variety of nonhemolytic adverse occurrences associated with blood transfusion has become a focus of clinical research and discussion within the transfusion medicine community.

Root cause analysis of non-infectious transfusion complications and the lessons learnt.

Preventing incompatible transfusions

Patients with blood group O are most at risk of dying from ABO incompatibility because they have the highest concentrations of potent antibodies directed against A and B antigens, according to studies in the United States.

Transfusion‐related acute lung injury

A screening programme to identify and exclude high-risk donors may be a worthwhile proposition and it is proposed that the National Blood Service should appoint a National co-ordinator to whom all suspected TRALI cases are notified.



Transfusion‐Associated Fatalities: Review of Bureau of Biologies Reports 1976–1978

Review of the 70 transfusion‐associated fatalities reported to the Bureau of Biologics (BOB) between 1976 and 1978 revealed 44 acute hemolytic reactions, two delayed hemolytic reactions, five

Special report: transfusion risks.

  • R. Walker
  • Medicine
    American journal of clinical pathology
  • 1987
The benefits of blood transfusion must be considered and evaluated in terms of risk factors relating to the adverse effects of transfusion, and transfusions should be avoided unless patient care would be compromised if withheld.

Estimating the incubation time distribution and expected number of cases of transfusion‐associated acquired immune deficiency syndrome

A mathematical model and nonparametric and parametric statistical analyses of recent data on TA‐AIDS indicate clearly the existing estimability problems and suggest about 1100 new cases to be reported between July 1988 and June 1989 and about 1500 more between July 1989 and June 1990.

Bacterial shock due to transfusion with Yersinia enterocolitica infected blood.

A fatal case (a 55-yr-old man) of bacterial shock and sepsis following a transfusion with erythrocytes infected with Yersinia enterocolitica serotype 03, is reported. The blood donor had slight

Escherichia coli sepsis from contaminated platelet transfusion.

This episode illustrates the continuing importance of sepsis as a cause of platelet transfusion reactions and demonstrates the usefulness of appropriate cultures and epidemiologic information in assessing the source.

Transfusion-acquired babesiosis and failure of antibiotic treatment.

The first case of babesiosis acquired in New Hampshire is reported and evidence indicating that the infection was transfusion acquired is cited, indicating potential for transmission of infection through blood donation.

The role of blood from HLA-homozygous donors in fatal transfusion-associated graft-versus-host disease after open-heart surgery.

The aplasia observed in graft-versus-host disease is presumably due to recognition by the donor's immune-reactive cells of histoincompatible antigens on the host's hematopoietic precursor cells.

Fatal Yersinia enterocolitica sepsis after blood transfusion.

A patient with fatal Yersinia enterocolitica sepsis was seen recently in the intensive care unit, and a whole-organism enzyme-linked immunosorbent assay of the donors' sera suggested a recent infection with Y enterocolite in an asymptomatic donor.

Effects of iron and desferrioxamine on infections with Yersinia enterocolitica

In vitro experiments indicated that Desferal promoted growth of Y. enterocolitica under iron-limiting conditions and suggested that the enhanced virulence of O8 yersiniae may be due to their comparatively low requirement for iron.

Yersinia enterocolitica.

The clinical and epidemiologic features of Yersinia enterocolitica are reviewed, as are aspects of its pathogenesis, diagnosis, treatment, and prevention.