Reporting sodium channel activity using calcium flux: pharmacological promiscuity of cardiac Nav1.5.

@article{Zhang2015ReportingSC,
  title={Reporting sodium channel activity using calcium flux: pharmacological promiscuity of cardiac Nav1.5.},
  author={Hongkang Zhang and Beiyan Zou and Fang Du and Kaiping Xu and Min Li},
  journal={Molecular pharmacology},
  year={2015},
  volume={87 2},
  pages={207-17}
}
Voltage-gated sodium (Nav) channels are essential for membrane excitability and represent therapeutic targets for treating human diseases. Recent reports suggest that these channels, e.g., Nav1.3 and Nav1.5, are inhibited by multiple structurally distinctive small molecule drugs. These studies give reason to wonder whether these drugs collectively target a single site or multiple sites in manifesting such pharmacological promiscuity. We thus investigate the pharmacological profile of Nav1.5… CONTINUE READING
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