Reporting on data monitoring committees in neonatal randomised controlled trials is inconsistent

@article{Perrem2017ReportingOD,
  title={Reporting on data monitoring committees in neonatal randomised controlled trials is inconsistent},
  author={Lucy Perrem and Sophie Gosling and I Ravikumar and A S Khashan and Jan Milet{\'i}n and Cornelius A Ryan and Eugene M Dempsey},
  journal={Acta Paediatrica},
  year={2017},
  volume={106},
  pages={30–33}
}
  • Lucy Perrem, Sophie Gosling, +4 authors Eugene M Dempsey
  • Published in Acta paediatrica 2017
  • Medicine
  • Acta Paediatrica
  • AIM To evaluate the reported use of data monitoring committees (DMCs), the frequency of interim analysis, prespecified stopping rules and early trial termination in neonatal randomised controlled trials (RCTs). METHODS We reviewed neonatal RCTs published in four high-impact general medical journals, specifically looking at safety issues including documented involvement of a DMC, stated interim analysis, stopping rules and early trial termination. We searched all journal issues over an 11-year… CONTINUE READING

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