Reporting Tumor Molecular Heterogeneity in Histopathological Diagnosis

@inproceedings{Mafficini2014ReportingTM,
  title={Reporting Tumor Molecular Heterogeneity in Histopathological Diagnosis},
  author={Andrea Mafficini and Eliana Amato and Matteo Fassan and Michele Simbolo and Davide Antonello and Caterina Vicentini and Maria Scardoni and Samantha Bersani and Marisa Gottardi and Borislav C Rusev and Giorgio Malpeli and Vincenzo Corbo and Stefano Barbi and Katarzyna O. Sikora and Rita T. Lawlor and Gianpaolo Tortora and Antonio Scarpa},
  booktitle={PloS one},
  year={2014}
}
BACKGROUND Detection of molecular tumor heterogeneity has become of paramount importance with the advent of targeted therapies. Analysis for detection should be comprehensive, timely and based on routinely available tumor samples. AIM To evaluate the diagnostic potential of targeted multigene next-generation sequencing (TM-NGS) in characterizing gastrointestinal cancer molecular heterogeneity. METHODS 35 gastrointestinal tract tumors, five of each intestinal type gastric carcinomas… CONTINUE READING

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