Reply to Watkins et al.: Whole-genome sequencing-based identification of diverse tandem duplicator phenotypes in human cancers.

@article{Menghi2016ReplyTW,
  title={Reply to Watkins et al.: Whole-genome sequencing-based identification of diverse tandem duplicator phenotypes in human cancers.},
  author={Francesca Menghi and Edison T. Liu},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={2016},
  volume={113 36},
  pages={E5259-60}
}
Watkins et al. (1) note that tandem duplications (TDs) are a feature of two distinct cancer phenotypes, distinguished based on TD span size (1 Kb–2Mb vs. 2–10Mb) and breast cancer 1 (BRCA1) status (inactivation vs. wildtype), present at different frequencies in triple-negative breast cancer (TNBC). The authors suggest that our recent study (2) only captures… CONTINUE READING