Reply to “Many hypotheses but no replication for the association between PDE4D and stroke”

@article{Gulcher2006ReplyT,
  title={Reply to “Many hypotheses but no replication for the association between PDE4D and stroke”},
  author={Jeffrey Robert Gulcher and Augustine Kong and S{\'o}lveig Gr{\'e}tarsd{\'o}ttir and Gudmar Thorleifsson and K{\'a}ri Stef{\'a}nsson},
  journal={Nature Genetics},
  year={2006},
  volume={38},
  pages={1092-1093}
}
maximum r2 of the 11 SNPs to G0 is ~0.2 (Fig. 1). As was observed in the data of the deCODE study1, the 0 allele of AC008818-1 determines the G0 haplotype perfectly and is in complete linkage disequilibrium (D′ = 1) with SNP45 (rs12188950). Further, the r2 (<0.1) between SNP45 and the 0 allele of AC008818-1 as well as the frequencies of the two-marker… CONTINUE READING