Reply to: Is one solution good enough?

  title={Reply to: Is one solution good enough?},
  author={Helen M. Berman and Kim Henrick and Haruki Nakamura and Eddy Arnold},
  journal={Nature Structural &Molecular Biology},
185 enable more robust virtual screening and lead optimization10 during drug design by allowing explicit incorporation of conformational heterogeneity and uncertainty into the screening and optimization technologies. Analysis of ensembles may provide insights into why a particular lead is not binding with the expected specificity or how the spatial limits… CONTINUE READING