Reply: Trimethylamine-N-Oxide and Heart Failure.

  title={Reply: Trimethylamine-N-Oxide and Heart Failure.},
  author={W H Wilson Tang and Stanley L. Hazen},
  journal={Journal of the American College of Cardiology},
  volume={66 1},
We thank Mr. McCarty and Dr. DiNicolantonio for their interest and their opinions regarding our discovery of a previously unappreciated role for the potential involvement of a specific gut microbiota–dependent pathway leading to higher circulating trimethylamine N -oxide (TMAO) levels that were