Replisome assembly and the direct restart of stalled replication forks

@article{Heller2006ReplisomeAA,
  title={Replisome assembly and the direct restart of stalled replication forks},
  author={Ryan C. Heller and Kenneth J Marians},
  journal={Nature Reviews Molecular Cell Biology},
  year={2006},
  volume={7},
  pages={932-943}
}
  • R. Heller, K. Marians
  • Published 1 December 2006
  • Biology, Medicine
  • Nature Reviews Molecular Cell Biology
Failure to reactivate either stalled or collapsed replication forks is a source of genomic instability in both prokaryotes and eukaryotes. In prokaryotes, dedicated fork repair systems that involve both recombination and replication proteins have been identified genetically and characterized biochemically. Replication conflicts are solved through several pathways, some of which require recombination and some of which operate directly at the stalled fork. Some recent biochemical observations… 

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