Replisome Assembly Reveals the Basis for Asymmetric Function in Leading and Lagging Strand Replication

@article{Yuzhakov1996ReplisomeAR,
  title={Replisome Assembly Reveals the Basis for Asymmetric Function in Leading and Lagging Strand Replication},
  author={Alexander Yuzhakov and Jennifer Turner and Mike O'Donnell},
  journal={Cell},
  year={1996},
  volume={86},
  pages={877-886}
}
The E. coli replicase, DNA polymerase III holoenzyme, contains two polymerases for replication of duplex DNA. The DNA strands are antiparallel requiring different modes of replicating the two strands: one is continuous (leading) while the other is discontinuous (lagging). The two polymerases within holoenzyme are generally thought to have asymmetric functions for replication of these two strands. This report finds that the two polymerases have equal properties, both are capable of replicating… CONTINUE READING