Replicative stress, stem cells and aging.

Abstract

DNA synthesis is a remarkably vulnerable phase in the cell cycle. In addition to introduction of errors during semi-conservative replication, the inherently labile structure of the replication fork, as well as numerous pitfalls encountered in the course of fork progression, make the normally stable double stranded molecule susceptible to collapse and… (More)
DOI: 10.1016/j.mad.2008.03.009

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