Replicative intermediates of hepatitis B virus in HepG2 cells that produce infectious virions.

@article{Sells1988ReplicativeIO,
  title={Replicative intermediates of hepatitis B virus in HepG2 cells that produce infectious virions.},
  author={Mary Ann Sells and Arthur Zelent and M Ia Shvartsman and George Acs},
  journal={Journal of virology},
  year={1988},
  volume={62 8},
  pages={2836-44}
}
Clonal cells derived from HepG2 cells transfected with a plasmid containing hepatitis B virus (HBV) DNA secrete hepatitis B surface antigen particles, nucleocapsids, and virions (M. A. Sells, M.-L. Chen, and G. Acs, Proc. Natl. Acad. Sci. USA 84:1005-1009, 1987) which elicit acute hepatitis in chimpanzees (G. Acs, M. A. Sells, R. H. Purcell, P. Price, R. Engle, M. Shapiro, and H. Popper, Proc. Natl. Acad. Sci. USA 84:4641-4644, 1987). We report here the initial characterization of the viral… CONTINUE READING

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