Replicative aging of human articular chondrocytes during ex vivo expansion.

  title={Replicative aging of human articular chondrocytes during ex vivo expansion.},
  author={Dominik Parsch and Tim H. Br{\"u}mmendorf and Wiltrud Richter and Joerg Fellenberg},
  journal={Arthritis and rheumatism},
  volume={46 11},
OBJECTIVE To investigate the contribution of clinical ex vivo expansion protocols to replicative aging of human chondrocytes. METHODS Primary human chondrocytes were cultured as monolayers after isolation from 7 articular cartilage specimens. Cells were passaged corresponding to 12-19 cell population doublings (cpd). Aliquots of the cells were collected from each passage and analyzed for telomere length and telomerase activity. RESULTS The rate of telomere shortening was heterogeneous… CONTINUE READING

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