Replicative Legionella pneumophila lung infection in intratracheally inoculated A/J mice. A murine model of human Legionnaires' disease.

@article{Brieland1994ReplicativeLP,
  title={Replicative Legionella pneumophila lung infection in intratracheally inoculated A/J mice. A murine model of human Legionnaires' disease.},
  author={Joan K. Brieland and P T Freeman and Robin Kunkel and Clarence E. Chrisp and Mary C. Hurley and Joseph C. Fantone and C N Engleberg},
  journal={The American journal of pathology},
  year={1994},
  volume={145 6},
  pages={1537-46}
}
The role of host immune responses in the pathogenesis of Legionnaires' disease is incompletely understood, due in part to the current lack of an animal model that is both susceptible to replicative Legionella pneumophila-induced lung infection and for which species-specific immunological reagents are available. We have developed a model of replicative L. pneumophila lung infection in intratracheally inoculated A/J mice. L. pneumophila was obtained in the exponential growth phase and inoculated… CONTINUE READING
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