Replication validity of genetic association studies

  title={Replication validity of genetic association studies},
  author={John P. A. Ioannidis and Evangelia E. Ntzani and Thomas A. Trikalinos and Despina G. Contopoulos-Ioannidis},
  journal={Nature Genetics},
The rapid growth of human genetics creates countless opportunities for studies of disease association. Given the number of potentially identifiable genetic markers and the multitude of clinical outcomes to which these may be linked, the testing and validation of statistical hypotheses in genetic epidemiology is a task of unprecedented scale. Meta-analysis provides a quantitative approach for combining the results of various studies on the same topic, and for estimating and explaining their… 
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