Replication timing of two human common fragile sites: FRA1H and FRA2G

@article{Pelliccia2008ReplicationTO,
  title={Replication timing of two human common fragile sites: FRA1H and FRA2G},
  author={Franca Pelliccia and Nazario Bosco and Angela Curatolo and Angela Rocchi},
  journal={Cytogenetic and Genome Research},
  year={2008},
  volume={121},
  pages={196 - 200}
}
The mammalian chromosomes present specific sites of gaps or breaks, the common fragile sites (CFSs), when the cells are exposed to DNA replication stress or to some DNA binding compounds. CFSs span hundreds or thousands of kilobases. The analysis of these sequences has not definitively clarified the causes of their fragility. There is considerable evidence that CFSs are regions of late or slowed replication in the presence of sequence elements that have the propensity to form secondary… 

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DNA replication stress drives fragile site instability.
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