Replication timing of genes and middle repetitive sequences.

@article{Goldman1984ReplicationTO,
  title={Replication timing of genes and middle repetitive sequences.},
  author={Michael A. Goldman and Gerald P. Holmquist and Mary C. Gray and L A Caston and Anita Nag},
  journal={Science},
  year={1984},
  volume={224 4650},
  pages={686-92}
}
DNA replication in mammals is temporally bimodal. "Housekeeping" genes, which are active in all cells, replicate during the first half of the S phase of cell growth. Tissue-specific genes replicate early in those cells in which they are potentially expressed, and they usually replicate late in tissues in which they are not expressed. Replication during the first half of the S phase is, therefore, a necessary but not sufficient condition for gene transcription. A change in the replication timing… CONTINUE READING

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