Replication timing and transcriptional control: beyond cause and effect-part III.

@article{RiveraMulia2002ReplicationTA,
  title={Replication timing and transcriptional control: beyond cause and effect-part III.},
  author={Juan Carlos Rivera-Mulia and David M. Gilbert},
  journal={Current opinion in cell biology},
  year={2002},
  volume={40},
  pages={168-178}
}
DNA replication is essential for faithful transmission of genetic information and is intimately tied to chromosome structure and function. Genome duplication occurs in a defined temporal order known as the replication-timing (RT) program, which is regulated during the cell cycle and development in discrete units referred to as replication domains (RDs). RDs correspond to topologically-associating domains (TADs) and are spatio-temporally compartmentalized in the nucleus. While improvements in… CONTINUE READING
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