Replication the association of 2q32.2-q32.3 and 14q32.11 with hepatocellular carcinoma.

  title={Replication the association of 2q32.2-q32.3 and 14q32.11 with hepatocellular carcinoma.},
  author={Wei Chen and Mingquan Wang and Zhen Zhang and Huayang Tang and Xianbo Zuo and Xiangling Meng and Mao-ming Xiong and Fusheng Zhou and Bo Liang and Fen Dai and Jun Fang and Jinping Gao and Jun Zhu and Yong Zhu and Hong Wan and Miaofeng Wang and Shixin Chan and Liangdan Sun},
  volume={561 1},
Hepatocellular carcinoma (HCC) is a malignant tumor. The morbidity and mortality of HCC tend to ascend and become a serious threat to the population health. Genetic studies of HCC have identified several susceptibility loci of HCC. In this study, we aim to replicate the association of these loci in our samples from Chinese population and further investigate the genetic interaction. We selected 16 SNPs within 1p36.22, 2q32.2-q32.3, 3p21.33, 8p12, 14q32.11 and 21q21.3 and genotyped in 507 HCC… Expand
PNPLA3 and TM6SF2 variants as risk factors of hepatocellular carcinoma across various etiologies and severity of underlying liver diseases
PNPLA3‐rs738409 and TM6SF2‐rs58542926 are inherited risk variants of HCC development in patients with ALD in a dose dependent manner and suggest a direct role in liver carcinogenesis. Expand
A new discovery of STAT4 single nucleotide polymorphisms associated with hepatocellular carcinoma risk in Chinese Han population: a case–control study
The association between four candidate single nucleotide polymorphisms (SNPs) in STAT4 genes and HCC risk in Chinese Han population was determined and rs11889341 showed outstanding association with HCCrisk. Expand
Association of STAT 4 genetic polymorphisms with biliary atresia in Chinese patients
Biliary atresia (BA) is a devastating disease of the liver characterized by progressive fibro-inflammatory obliteration in neonates. Without effective treatment, end stage of liver, will ultimatelyExpand
Association of STAT3 and STAT4 polymorphisms with susceptibility to chronic hepatitis B virus infection and risk of hepatocellular carcinoma: a meta-analysis
The meta-analysis showed that STAT3 rs1053004 polymorphism may be the risk for developing chronicHBV infection but not associated with HCC, and indicates that STAT4 rs7574865 polymorphism increased the risk of chronic HBV infection and HCC. Expand
Systematic Review and Meta-Analysis on the Association between Polymorphisms in Genes of IL-12 Signaling Pathway and Hepatocellular Carcinoma Risk
The study suggests that STAT4-rs7574865 is a risk factor for HCC, and fails to uncover any significant association between other polymorphisms in genes of IL-12 signaling pathway and HCC risk. Expand
Clinicopathological significance of STAT4 in hepatocellular carcinoma and its effect on cell growth and apoptosis
STAT4 might play a vital role in development of HCC, via influencing cell growth and apoptosis, as a tumor suppressor. Expand
Genome-wide association study: new genetic insights into HBV/HCV-related hepatocellular carcinoma genomes
The specific genetic mutations responsible for the progression from CHB or CHC to HCC have been identified and more functional experiments are warranted to confirm the precise roles of these genetic mutations in the correlations between HBV/HCV and HCC for the future clinical application. Expand
Meta‐analysis reveals an association between signal transducer and activator of transcription‐4 polymorphism and hepatocellular carcinoma risk
A meta‐analysis approach was used to comprehensively investigate the correlation between STAT4 polymorphism and HCC risk based on previously published reports, and indicated associations with various autoimmune diseases. Expand


Genome-wide association study identifies 1p36.22 as a new susceptibility locus for hepatocellular carcinoma in chronic hepatitis B virus carriers
The findings provide evidence that the 1p36.22 locus confers susceptibility to HBV-related HCC, and suggest that KIF1B-, UBE4B- or PGD-related pathways might be involved in the pathogenesis of this malignancy. Expand
Genome-wide association study identifies a susceptibility locus for HCV-induced hepatocellular carcinoma
A previously unidentified locus in the 5′ flanking region of MICA on 6p21.33 was found to be strongly associated with HCV-induced HCC and the risk allele of rs2596542 was associated with lower soluble MICA protein levels in individuals withHCV- induced HCC. Expand
Genetic variants in STAT4 and HLA-DQ genes confer risk of hepatitis B virus–related hepatocellular carcinoma
To identify genetic susceptibility loci for hepatitis B virus (HBV)-related hepatocellular carcinoma (HCC) in the Chinese population, a genome-wide association study in 2,514 chronic HBV carriers followed by a 2-stage validation among 6 independent populations of chronicHBV carriers showed that HCC risk was significantly associated with two independent loci. Expand
Variation in the DEPDC5 locus is associated with progression to hepatocellular carcinoma in chronic hepatitis C virus carriers
It is suggested that common variants within the DEPDC5 locus affect susceptibility to HCC in Japanese individuals with chronic HCV infection. Expand
Genome-Wide Association Study of Hepatocellular Carcinoma in Southern Chinese Patients with Chronic Hepatitis B Virus Infection
Variations at chromosome 8p12 may promote HCC in patients with HBV, and results from sequence analysis and in-vitro protein translation study suggest that the transcript might function as a long non-coding RNA. Expand
Genome-wide association study in a Chinese Han population identifies nine new susceptibility loci for systemic lupus erythematosus
This study not only advances the understanding of the genetic basis of SLE but also highlights the value of performing GWAS in diverse ancestral populations. Expand
Genetic variations at loci involved in the immune response are risk factors for hepatocellular carcinoma
Combined analysis of CNV, individual SNPs, and pathways suggest that HCC susceptibility is mediated by germline factors affecting the immune response and differences in T‐cell receptor processing. Expand
Genome-Wide Scan Identifies TNIP1, PSORS1C1, and RHOB as Novel Risk Loci for Systemic Sclerosis
The genetic signal of association with TNIP1 variants, together with tissular and cellular investigations, suggests that this pathway has a critical role in regulating autoimmunity and SSc pathogenesis. Expand
Meta-Analysis of Genome-Wide Association Studies in Celiac Disease and Rheumatoid Arthritis Identifies Fourteen Non-HLA Shared Loci
A meta-analysis of two published GWAS on celiac disease and rheumatoid arthritis confirmed that 4 gene loci previously established in either CD or RA are associated with the other autoimmune disease at combined P<5×10−8, and implicate antigen presentation and T-cell activation as a shared mechanism of disease pathogenesis. Expand
Meta-analysis of genome-wide association studies in celiac disease and rheumatoid arthritis identifies fourteen non-HLA shared loci
Background and objectives Epidemiology and candidate gene studies indicate a shared genetic basis for celiac disease (CD) and rheumatoid arthritis (RA), but the extent of this sharing has not beenExpand