Replication test for association of the IL-1 receptor antagonist gene, IL1RN, with attention-deficit/hyperactivity disorder.

@article{Misener2004ReplicationTF,
  title={Replication test for association of the IL-1 receptor antagonist gene, IL1RN, with attention-deficit/hyperactivity disorder.},
  author={Virginia L. Misener and Russell J. Schachar and Abel Ickowicz and Molly M. Malone and Wendy Roberts and Rosemary Tannock and James L Kennedy and Tejaswee Pathare and Cathy L. Barr},
  journal={Neuropsychobiology},
  year={2004},
  volume={50 3},
  pages={231-4}
}
Attention-deficit/hyperactivity disorder (ADHD) has a strong genetic basis, and aberrant brain dopaminergic and noradrenergic activity is implicated in its etiology. Interleukin-1 (IL-1), its antagonist, IL-1Ra, and IL-1 receptors are all present in the brain, and IL-1 has been shown to influence both dopaminergic and noradrenergic function. Recently… CONTINUE READING