Replication stress checkpoint signaling controls tRNA gene transcription

Abstract

In budding yeast, the transcriptional machinery at tRNA genes naturally interferes with replication in a way that can promote chromosome breakage. Here we show that a signaling module composed of core components of the replication stress checkpoint pathway represses this fork-pausing machinery in normally cycling and genotoxin-treated cells. Specifically… (More)
DOI: 10.1038/nsmb.1857

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