Replication stalling by catalytically impaired Twinkle induces mitochondrial DNA rearrangements in cultured cells.

@article{Pohjoismki2011ReplicationSB,
  title={Replication stalling by catalytically impaired Twinkle induces mitochondrial DNA rearrangements in cultured cells.},
  author={Jaakko L O Pohjoism{\"a}ki and Steffi Goffart and Johannes N. Spelbrink},
  journal={Mitochondrion},
  year={2011},
  volume={11 4},
  pages={
          630-4
        }
}
Pathological mitochondrial DNA (mtDNA) rearrangements have been proposed to result from repair of double-strand breaks caused by blockage of mitochondrial DNA (mtDNA) replication. As mtDNA deletions are seen only in post-mitotic tissues, it has been suggested that they are selected out in actively dividing cells. By electron microscopy we observed rearranged mtDNA molecules in cultured human cells expressing a catalytically impaired helicase. As these molecules were undetectable by PCR, we… CONTINUE READING

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