Replication stalling and DNA microsatellite instability.

@article{Gadgil2017ReplicationSA,
  title={Replication stalling and DNA microsatellite instability.},
  author={Rucha Gadgil and Joanna Barthelemy and Tracey Lewis and M. Leffak},
  journal={Biophysical chemistry},
  year={2017},
  volume={225},
  pages={38-48}
}
Microsatellites are short, tandemly repeated DNA motifs of 1-6 nucleotides, also termed simple sequence repeats (SRSs) or short tandem repeats (STRs). Collectively, these repeats comprise approximately 3% of the human genome Subramanian et al. (2003), Lander and Lander (2001) [1,2], and represent a large reservoir of loci highly prone to mutations Sun et al. (2012), Ellegren (2004) [3,4] that contribute to human evolution and disease. Microsatellites are known to stall and reverse replication… CONTINUE READING
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