Replication slippage involves DNA polymerase pausing and dissociation.

  title={Replication slippage involves DNA polymerase pausing and dissociation.},
  author={Enrique Viguera and Danielle Canceill and S. Dusko Ehrlich},
  journal={The EMBO journal},
  volume={20 10},
Genome rearrangements can take place by a process known as replication slippage or copy-choice recombination. The slippage occurs between repeated sequences in both prokaryotes and eukaryotes, and is invoked to explain microsatellite instability, which is related to several human diseases. We analysed the molecular mechanism of slippage between short direct repeats, using in vitro replication of a single-stranded DNA template that mimics the lagging strand synthesis. We show that slippage… CONTINUE READING

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