Replication protein A physically interacts with the Bloom's syndrome protein and stimulates its helicase activity.

@article{Brosh2000ReplicationPA,
  title={Replication protein A physically interacts with the Bloom's syndrome protein and stimulates its helicase activity.},
  author={Robert M. Brosh and Ji Liang Li and Mark Kulie Kenny and Julia K. Karow and Marcus P. Cooper and Raichal P Kureekattil and Ian D. Hickson and Vilhelm A. Bohr},
  journal={The Journal of biological chemistry},
  year={2000},
  volume={275 31},
  pages={
          23500-8
        }
}
Bloom's syndrome is a rare autosomal recessive disorder characterized by genomic instability and predisposition to cancer. BLM, the gene defective in Bloom's syndrome, encodes a 159-kDa protein possessing DNA-stimulated ATPase and ATP-dependent DNA helicase activities. We have examined mechanistic aspects of the catalytic functions of purified recombinant BLM protein. Through analyzing the effects of different lengths of DNA cofactor on ATPase activity, we provide evidence to suggest that BLM… CONTINUE READING

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Interaction between BLM and hRPA

Y. S. Seo, S. H. Lee, J. Hurwitz
  • J. Biol
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